We are glad to announce that our CarBon ESR 7 Farhad Chariyev Prinz recently won a small award at the conference Bioengineering in Ireland (https://binirl.com)

Farhad has been awarded “Best Mechanobiology Track Oral Presentation Early Researcher Category”. 

Title and summary of Farhad’s oral presentation:

Identification of mechanical cues that promote chondrogenesis of mesenchymal stem cells

Due to the avascular and alymphatic nature of our articular cartilage, its regenerative capacity in case of an injury is very limited. Conventional therapies, including articular chondrocyte implantation or microfracture, have drawbacks like donor site morbidity or insufficient donor supply. Cartilage tissue engineering (TE) represents a promising alternative and is based on a combination of mesenchymal stem cells (MSCs), 3D scaffolds and growth factors in order to create functional native-like cartilage tissues. Although side effects like donor site morbidity can be avoided with this approach, the engineered tissues are still inferior to the native cartilage. In this context, mechanical loading has been identified as an additional factor that is able to steer MSC differentiation into matrix producing chondrocytes.

The goal of this study was to optimise properties of fibrin hydrogels for TE and mechanobiology studies, including biomaterial mechanics, opacity and cell viability. Subsequently, the response of MSCs embedded within fibrin hydrogels to dynamic compression (DC) was investigated and the expression of chondrogenic markers were examined.