Project Description


The aim of the thesis is to develop a multiscale model of osteochondrogenic differentiation in a bioreactor environment and other experimental set-ups typically used in skeletal tissue engineering. The state of mechanical loading around the tibia, knee joint and growing skeletal tissue in a bioreactor is to be calculated from computational models using finite element method. Subsequently, a computer model of tissue regeneration in osteochondral and large bone defects is to be developed with appropriate mechanical properties of the involved biological tissue. After this, the tissue regeneration model is to be coupled through a multiscale approach to an intracellular network model capturing the biological regulation of the chondrocyte. This multiscale model developed can be used to suggest interesting and therapeutic targets for osteochondral problems.