Project Description

The purpose of my project is to investigate the cartilage tissue response to mechanical stimulation, exposing biological bone-cartilage samples to different types and magnitudes of loading. The main focus is on the behavior exhibited by the tissues and the resulting inhibition or stimulation of the endochondral ossification process. A further aim is to obtain a disease model, mimicking osteoarthritis affected tissue, by setting up a platform capable of inducing degeneration of the cartilage surface and/or bulk tissue in a controlled and reproducible way. This would let us investigate and test new techniques and methods for promoting cartilage regeneration in a relevant environment. Deeper understanding of such topics could play a key role in the treatment of the most common skeletal joint ailments