Project Description

The main goal of my research is to identify novel extracellular matrix molecules to improve the design of the biomaterials that are being currently used for the treatment of skeletal diseases, such as bone defects and osteoarthritis. Specifically, I am focused on the role that certain extracellular matrix proteins and their fragments play in endochondral ossification. I am interested in their ability to promote or inhibit vascularisation, mineralisation and to determine cell fate in the formation of cartilage or bone. Once novel bioactive factors are identified, I expect to further test them in vivo to report whether they could be further tested on clinical trials for the treatment of skeletal diseases.