The main goal of this research is to develop novel collagen-based scaffolds in order to induce (i.e. bone repair) or prevent matrix vascularisation (i.e. cartilage repair) and to evaluate their potential for either treating large bone or cartilage defects in the treatment of osteoarthritis.
Specifically, this project will develop and improve SurgaColl’s patented technologies based on osteo/chondro inductive collagen hydroxyapatite/hyaluronic acid scaffolds (i.e. separate layers within the marketed ChondroCollTM device). We will aim to understand if the incorporation of the pro-/anti-chondrogenic extracellular matrix (ECM) components (identified by Carbon) into ChondroColl cartilage and bone layers, can modify the capability of these 3D biomaterials to control bone and cartilage repair. The ultimate goal is to make a significant improvement into the field, realizing versatile scaffolds able to be carrier systems for protein, paracrine and cell/gene-based therapeutics for tissue regeneration.