CarBon will train 14 high potential scientists to combine knowledge of cartilage & bone developmental biology, pathobiology and tissue engineering with skills in cell culture, animal models, proteomics, biomaterial development, bioreactors and computational modelling.

Exchange of knowledge and multidisciplinary collaboration between these fields of research will raise the next generation of researchers with the skills, multidisciplinary knowledge and on-the-job training experience necessary to tackle all aspects of bone and cartilage disease and repair.

CarBon will identify:

  1. the specific factors secreted by chondrogenic cells,
  2.  the effect of components of the cartilage extra-cellular matrix and
  3. the interactions with the mechanical environment that determine whether cartilage either undergoes endochondral ossification or resists these processes and maintains stable cartilage.

Multidisciplinary approach

Elucidating this triumvirate will allow the 14 innovative, multidisciplinary and socially responsible young scientists to take critical steps towards development of approaches to influence the fate of the cartilage tissues with the ultimate goal of developing new treatments for bone defects and osteoarthritis. To reach our goal of training these 14 early stage researchers we have defined 3 research objectives.

Research objectives

To increase understanding of the role and interplay of cell secreted factors, extracellular matrix components and mechanical loading in cartilage and bone formation and repair by combining knowledge and skills from developmental biology, pathobiology and biomedical engineering.

To use the combined knowledge and skills of matrix biology and tissue engineering to develop novel, biologically inspired biomaterials for the formation of stable cartilage and vascularised bone.

To use knowledge of cell biology, proteomics, mechano- and pathobiology integrated by computational modelling to identify and to pursue drug targetable components for bone healing and osteoarthritis.